Pregna-3,5-diene-6-carboxaldehyde, 17-(acetyloxy)-3-methoxy-20-oxo-
oxyma
CAS: 57361-81-6
Molecular Formula: C25H34O5
Pregna-3,5-diene-6-carboxaldehyde, 17-(acetyloxy)-3-methoxy-20-oxo- - Names and Identifiers
| Name | oxyma |
| Synonyms | oxyma 17-(Acetyloxy)-3-Methoxy-20-oxo-pregna-3,5-diene-6-carboxaldehyde Pregna-3,5-diene-6-carboxaldehyde, 17-(acetyloxy)-3-methoxy-20-oxo- |
| CAS | 57361-81-6 |
Pregna-3,5-diene-6-carboxaldehyde, 17-(acetyloxy)-3-methoxy-20-oxo- - Physico-chemical Properties
| Molecular Formula | C25H34O5 |
| Molar Mass | 414.53 |
| Density | 1.16±0.1 g/cm3(Predicted) |
| Melting Point | 205-208 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) |
| Boling Point | 546.9±50.0 °C(Predicted) |
Pregna-3,5-diene-6-carboxaldehyde, 17-(acetyloxy)-3-methoxy-20-oxo- - Upstream Downstream Industry
| Downstream Products | 17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate |
Pregna-3,5-diene-6-carboxaldehyde, 17-(acetyloxy)-3-methoxy-20-oxo- - Introduction
Oxyma (also known as HOBt, 1-hydroxyphenyl-4, 5-diphenylimidazole) is a common chemical reagent with the following characteristics:
1. Nature: Oxyma is a white crystal, soluble in ethanol, acetic acid and dimethyl sulfoxide and other organic solvents. It is stable in solution and does not readily decompose.
2. Uses: Oxyma is mainly used as a condensing agent to promote the condensation reaction of amines and acid anhydrides. It can provide a stable oxoimine intermediate, and inhibit the oxidation or aggregation of amino acids of the polypeptide chain during the condensation process, thereby improving the selectivity and yield of the reaction. Therefore, Oxyma is widely used in peptide synthesis, amino acid synthesis, deprotection reaction and other organic synthesis fields.
3. Preparation method: Oxyma can be prepared by the reaction of phenyl isourea mercury salt and 4,5-diphenyl imidazole, and then converted to hydroxyphenyl isourea chloride, finally the chloride is converted to Oxyma by reaction of ethanol and a base.
4. Safety Information: Oxyma has no obvious harm to human body and environment under regular operating conditions. However, as a chemical reagent, it is still necessary to follow regular laboratory safety practices, such as wearing personal protective equipment, avoiding direct contact with skin and eyes, and maintaining good ventilation. In addition, Oxyma should avoid contact with organic phosphorus compounds and other substances that are prone to reaction during storage to prevent accidents.
1. Nature: Oxyma is a white crystal, soluble in ethanol, acetic acid and dimethyl sulfoxide and other organic solvents. It is stable in solution and does not readily decompose.
2. Uses: Oxyma is mainly used as a condensing agent to promote the condensation reaction of amines and acid anhydrides. It can provide a stable oxoimine intermediate, and inhibit the oxidation or aggregation of amino acids of the polypeptide chain during the condensation process, thereby improving the selectivity and yield of the reaction. Therefore, Oxyma is widely used in peptide synthesis, amino acid synthesis, deprotection reaction and other organic synthesis fields.
3. Preparation method: Oxyma can be prepared by the reaction of phenyl isourea mercury salt and 4,5-diphenyl imidazole, and then converted to hydroxyphenyl isourea chloride, finally the chloride is converted to Oxyma by reaction of ethanol and a base.
4. Safety Information: Oxyma has no obvious harm to human body and environment under regular operating conditions. However, as a chemical reagent, it is still necessary to follow regular laboratory safety practices, such as wearing personal protective equipment, avoiding direct contact with skin and eyes, and maintaining good ventilation. In addition, Oxyma should avoid contact with organic phosphorus compounds and other substances that are prone to reaction during storage to prevent accidents.
Last Update：2024-04-09 20:52:54
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